Thursday, February 28, 2013

Scientists discover molecule that does double duty in stopping asthma attacks

Thursday, February 28, 2013

Scientists from Brigham and Women's Hospital are on the brink of the next treatment advancement that may spell relief for the nearly nineteen million adults and seven million children in the United States suffering from asthma. The scientists discovered two new drug targets in the inflammatory response pathway responsible for asthma attacks.

The study will be published on February 27, 2013 in Science Translational Medicine.

Researchers studied the lungs and blood of 22 people with mild and severe asthma. They saw that immune cells called natural killer cells and type 2 innate lymphoid cells played significant roles in airway inflammation in study participants with severe asthma.

Natural killer cells decreased airway inflammation by encouraging programmed cell death in immune cells called eosinophils, whereas type 2 innate lymphoid cells promoted airway inflammation by secreting cell-signaling molecules called interleukin-13.

Both mechanisms were controlled by a molecule called lipoxin A4 which is responsible for resolving inflammation. To achieve this, lipoxin A4 acted in both pro-resolving and anti-inflammatory ways. The researchers saw that lipoxin A4 encouraged natural killer cells to decrease inflammation by facilitating eosinophil cell death. Lipoxin A4 also discouraged type 2 innate lymphoid cells from promoting inflammation by blocking interleukin-13 secretion.

"Stopping airway inflammation is similar to putting out a forest fire," said Bruce Levy, MD, Pulmonary and Critical Care Medicine Division, BWH Department of Internal Medicine, senior study author. "Firefighters tackle forest fires in two ways?dousing the fire with water and clearing away dry brush that could fuel the fire. Lipoxin A4 does just that to resolve inflammation. It is an airway inflammation fighter that performs the double duty of dampening pathways that ignite inflammation while at the same time clearing away cells that fuel inflammation."

In previous studies, Levy and his team discovered that lipoxin A4 production was defective in patients with severe asthma. Together with their new findings, this observation provides researchers and drug manufacturers with a new direction toward boosting lipoxin A4 in severe asthmatics when designing next-generation asthma therapies.

"Most patients with severe asthma have chronic airway inflammation that never fully resolves. This can lead to daily and often disabling symptoms despite available therapies. Our study provides new information on cellular targets that regulate inflammation and will enable the development of lipoxin-based therapeutics to decrease chronic inflammation in asthma and other diseases." said Levy.

###

Brigham and Women's Hospital: http://www.brighamandwomens.org

Thanks to Brigham and Women's Hospital for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 52 time(s).

Source: http://www.labspaces.net/127055/Scientists_discover_molecule_that_does_double_duty_in_stopping_asthma_attacks

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How to make a legal thriller less thrilling (photo gallery) - ABA Journal

Law in Popular Culture

When we challenged our readers in last week's Question of the Week to come up with less-interesting titles for well-known legal movies, they truly delivered. We chose just a handful of the answers to make mockups of what those movie posters might look like.

Other popular themes that readers flocked to were Anatomy of a Murder (Anatomy of a Misdemeanor, Anatomy of an SEC Filing, Anatomy of a Junk Car Ordinance Violation); 12 Angry Men (12 Mildly Disgruntled Men, 12 Annoyed Dudes, A Dozen Average Folks, 12 Men Anticipating the Free Lunch); A Time to Kill (A Time to Bill, A Time to Yell, A Time to Misdemeanor Assault); and A Few Good Men (A Few Good Pens, Some OK Lawyers, Several Men of Various Quality). Do yourself a favor and go read the whole thing.

Source: http://www.abajournal.com/news/article/how_to_make_a_legal_thriller_less_thrilling_photo_gallery/

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Novel combination therapy shuts down escape route, killing glioblastoma tumor cells

Novel combination therapy shuts down escape route, killing glioblastoma tumor cells

Wednesday, February 27, 2013

Glioblastoma, the most common and lethal form of brain tumor in adults, is challenging to treat because the tumors rapidly become resistant to therapy. As cancer researchers are learning more about the causes of tumor cell growth and drug resistance, they are discovering molecular pathways that might lead to new targeted therapies to potentially treat this deadly cancer.

Scientists at the Ludwig Institute for Cancer Research in San Diego worked collaboratively across the laboratories of Drs. Paul Mischel, Web Cavenee and Frank Furnari to investigate one such molecular pathway called the mammalian target of rapamycin or mTOR. This signaling pathway is hyperactivated in close to 90 percent of glioblastomas and plays a critical role in regulating tumor growth and survival. Therapies that inhibit mTOR signaling are under investigation as drug development targets, but results to date have been disappointing: mTOR inhibitors halt the growth but fail to kill the tumor cells.

A study published this week in the Proceedings of the National Academy of Sciences uncovers an unexpected but important molecular mechanism of mTOR inhibitor resistance and identifies a novel drug combination that reverses this resistance.

The story begins with a closer look at a gene-encoded protein called promyleocytic leukemia gene or PML. The study investigators explored the role of PML in causing resistance to mTOR inhibitor treatment. They found that when glioblastoma patients are treated with drugs that target the mTOR pathway, the levels of PML rise dramatically. Further, they showed that PML upregulation made the tumor cells resistant to mTOR inhibitors, and that if they suppressed the ability of the tumor cells to upregulate the PML protein, the tumor cells died in response to the mTOR inhibitor therapy.

"When we looked at cells in in vivo models and patients treated in the clinic, it became clear that the glioblastoma cells massively regulated PML enabling them to escape the effects of mTOR inhibitor therapy," reported senior author Paul Mischel, MD, Ludwig Institute member based at the University of California at San Diego.

"Our team hypothesized that if we could use a pharmacological approach to get rid of PML and combine it with an mTOR inhibitor, it could change the response from halting growth to cell death. The question was how?" added Mischel.

Previous research had shown that the use of low-dose arsenic could cause degradation of the PML protein in patients with leukemia. The team hypothesized that if arsenic could degrade PML, it may reverse resistance to mTOR inhibitors. The combination of mTOR and low-dose arsenic in mice indeed showed a synergistic effect, with massive tumor cell death along with very significant shrinkage of the tumor in mice with no ill side effects.

"Current therapy upregulates PML, turning off the mTOR signaling pathway. The tumor cells hide, waiting for the target signal to return," said Mischel. "When low-dose arsenic is added, not only does it stop the cell from returning, it shuts down the escape route killing the tumor cell."

These results present the first clinical evidence that mTOR inhibition promotes PML upregulation in mice and patients, and that it mediates drug resistance. The clinical relevance was confirmed when researchers looked at before- and after-treatment tissue samples from patients treated with mTOR inhibitors, confirming that PML goes up significantly in post treatment of mTOR inhibitors.

"These data suggest a new approach for potential treatment of glioblastoma," said Mischel. "We are moving forward to test that possibility in people."

Post-doctoral students Akio Iwanami and Beatrice Gini from the Mischel lab as well as Ciro Zanca from the Furnari/Cavenee lab, also contributed significantly to this paper.

###

Ludwig Institute for Cancer Research: http://www.licr.org

Thanks to Ludwig Institute for Cancer Research for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 36 time(s).

Source: http://www.labspaces.net/127038/Novel_combination_therapy_shuts_down_escape_route__killing_glioblastoma_tumor_cells

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Wedding Dress from Davidslove - ArticlesWide.com

  • Try on a variety of dresses. A completely different style just might surprise you!
  • Clip pictures from bridal magazines and shop online first. Find dresses that have features that you like and begin to form an image in your mind of what you might like: for example, if you narrow down the neckline, length and amount of beading before you set out to the stores, and youll be able to limit your selection to dresses that meet your needs.
  • If you're shopping at a bridal store, bring along a friend whose opinion you trust. Include your mother if appropriate.
  • Bring the same size heel you expect to wear at the wedding.
  • Don't skip looking checking out "on-the-rack" stores, outlet stores or trunk shows. You could find the dress of your dreams and save a boatload of money.
  • Take home a fabric swatch to match with your shoes, veil and accessories. Carry it with you in a baggy in your purse so youve always got it on hand. You never know when it might come in handy.

Made to Order

There are a variety of reasons why a bride would choose to have a dress custom made: she knows what she wants and apparently no one else does, she wants to design it herself or have someone she knows design it, she wants more control over the final outcome of the dress, she wants more flexibility in the construction of it, she appreciates the ability to customize any portion of it, etc. The reasons are endless, and theyre good! If you plan to have your dress made for you, be sure to allow at least six months for the process. Get in touch with the seamstress or designer as soon as possible to avoid last minute time crunches and panic.

If youre looking for a seamstress or designer, your best source of references is friends and family. Also, be sure to work out a payment policy and schedule up front and get it in writing to ensure that there is no confusion.

Body Type

Finding a dress that you love AND that flatters your body type is a battle and a half. But its one worth pursuing, because a dress that looks great on your will make you feel like a million dollars.

This guide will help you determine your body shape, and what features can best flatter what youve got.

Triangle - hips are wider than bust and shoulders. The goal: minimize lower body and create the illusion of additional upper body width.

  • Create height with an elongated waistline.
  • Wear full sleeves to create the appearance of wider shoulders.
  • Full skirts hide heavy hips and legs.
  • Draw the eye upward by selecting a decorative bodice or details at the neckline.
  • Avoid bulky or straight skirts.

Reverse Triangle - upper body is wider than the lower body. The goal: emphasize lower body width.

  • A simple bodice will minimize the upper body width, so will unadorned sleeves.
  • Avoid high necklines and narrow skirts.
  • Choose a detailed skirt to draw the eye downward.
  • Create additional height with an elongated waistline, for example, a dropwaist.

Hourglass - larger bust and hips, small waist. The goal: balance.

  • Avoid high waistlines and necklines.
  • Emphasize a small waist with a fitted waistline.
  • Soft gathered skirts disguise hips and draw attention to the waistline; A-line dresses also work well.
  • Use details or embellishments wisely: bodice detail such as beading or lace will bring the eye upward and emphasize the upper body.
  • Consider an open neckline to flatter the shoulder line and bring the eye upwards.

Rectangle - long and narrow without a strongly defined waistline. Emphasize width and avoid long vertical lines.

  • Detailed sleeves will draw the eye outward.
  • An open neckline or off the shoulder look will broaden the shoulder line.
  • A full skirt with horizontal details, for example horizontal ribbon trim from the waistline to the hem.
  • Avoid high or drop waists, instead go with a fitted waist.

Below the Neck

The neckline you choose should flatter your face and body shape. If your shoulders are narrow and you want them to appear wider you will want a wide neckline that will broaden. If you have broad shoulders that you would like to appear narrower then you should select a neckline that is narrow. Here are some guidelines on the best necklines to suit the shape of your face:

  • Square - Scoop, round or V-necklines are best.
  • Round - Scoop, angular or V-necklines. Avoid high necklines.
  • Oval - Any type of neckline works well.
  • Oblong - Round or square necklines. The objective is to widen the face.
  • Heart - Any type of neckline works well.
  • Diamond - Wide open necklines and rounded necklines. Avoid V-necks.
  • Pear - V-neck. The goal is to lengthen and narrow the bottom portion of the face.

Other Figure-Flattering Tricks

If you want to:

  • Appear taller - High neckline, empire waist, short-sleeved or sleeveless dress with gloves.
  • Appear slender - High waistlines such as princess style or A-line; utilize vertical lines in fabric or trim details; scoop necks are also affective. Avoid ruffles, puffy sleeves and clingy fabrics.
  • De-emphasize the bust line - Scoop necks, high necklines and v-necks. Avoid empire or cinched waists.
  • De-emphasize height - Drop waist, wide belt, waistline adornments. Your height enables you to wear a hat or dramatic veil without being overpowered.
  • Appear less slender - Heavier fabrics, bodice details, gathered, large sleeves.

Plus Size Considerations

Plus size women look their very best on their wedding day when they find a style of gown that flatters and fits their body type. Look for a style that slims the body. Don't worry about ordering a particular size. Order by measurements so that the dress doesn't pull or bind anywhere. When a gown pulls and forms wrinkles, it's a sign the dress is too tight and it will make you look larger.

Princess seaming will elongate the body and lace placement will pull the eye away from problem areas. If your bustline is an asset, by all means, play it up with a sweetheart or V-neckline. If you have beautiful shoulders, consider an off-the-shoulder gown. If youve got a small waistline but large hips, try on some ball gowns with a basque waistline.

A Note About Undergarments

Searching out wedding day lingerie isnt just a luxury, its a necessity. It can make or break how your dress fits you. This day, perhaps more than any other, calls for a properly fitted bra or complete underwear set to reduce unsightly bulges and pinches. And the wedding day is not a good day to first wear this lingerie. As silly as it might feel, wear it around in advance, so you know before the big day whether it feels comfortable and isnt poking you somewhere.

Oh yeah, and make sure its pretty. After the wedding, theres always the wedding night!

http://davidslove.com/

Source: http://www.articleswide.com/article/18084-Wedding_Dress_from_Davidslove.html

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Wednesday, February 27, 2013

Video: Blood vessels 'sniff' gut microbes to regulate blood pressure

Wednesday, February 27, 2013

Researchers at The Johns Hopkins University and Yale University have discovered that a specialized receptor, normally found in the nose, is also in blood vessels throughout the body, sensing small molecules created by microbes that line mammalian intestines, and responding to these molecules by increasing blood pressure. The finding suggests that gut bacteria are an integral part of the body's complex system for maintaining a stable blood pressure.

A description of the research, conducted in mice and test tubes, appeared online Feb. 11 in the journal Proceedings of the National Academy of Sciences.

"The contribution that gut microbes apparently make to blood pressure regulation and human health is a surprise," says Jennifer Pluznick, Ph.D., assistant professor of physiology at the Johns Hopkins University School of Medicine. "There is still much to learn about this mechanism, but we now know some of the players and how they interact," she adds.

Pluznick says that several years ago, thanks to a "happy coincidence," she found ? in the kidney ? some of the same odor-sensing proteins that give the nose its powers. Focusing on one of those proteins, olfactory receptor 78 (Olfr78), her team specifically located it in the major branches of the kidney's artery and in the smaller arterioles that lead into the kidney's filtering structures. Olfr78 also turned up in the walls of small blood vessels throughout the body, she says, particularly in the heart, diaphragm, skeletal muscle and skin.

To figure out which molecules bind and activate Olfr78, the scientists programmed cells to have Olfr78 protein receptors on their surface. They also gave these same cells the ability to start a light-producing chemical reaction whenever Olfr78 is activated. By adding different cocktails of molecules to the cells and measuring the light the cells produced, they homed in on a single mixture that activated Olfr78. They then tested each component in that mix and found that only acetic acid (a.k.a. vinegar) bound Olfr78 and caused the reaction.

Acetic acid and its alter ego, acetate, are part of a group of molecules known as short chain fatty acids (SCFAs). When the team tested other molecules in this group, they found that propionate, which is similar to acetate, also binds Olfr78. In the body of mammals, including humans, SCFAs are made when zillions of bacteria lining the gut digest starch and cellulose from plant-based foods. The SCFAs are absorbed by the intestines into the blood stream, where they can interact with Olfr78.

To pinpoint the effect of Olfr78, the scientists gave SCFAs to mice missing the Olfr78 gene and found that the rodents' blood pressure decreased, suggesting that SCFAs normally induce Olfr78 to elevate blood pressure. However, when they gave SCFAs to normal mice with intact Olfr78, they did not see the expected increase in blood pressure, but rather a decrease, though it was less pronounced than before.

To test the effect of reducing the SCFAs available to Olfr78, the team gave mice a three-week course of antibiotics to wipe out the gut microbes responsible for SCFA production. In this case, normal mice showed very little change in blood pressure, but mice without Olfr78 experienced an increase in blood pressure, suggesting that there were other factors involved in the Olfr78/SCFA/blood pressure relationship.

The mystery was solved, Pluznick says, when the team examined mice lacking Gpr41, a non-smell-related protein receptor located in blood vessel walls that also binds SCFAs. When SCFAs bind to Gpr41, blood pressure is decreased. The researchers eventually discovered that Olfr78 and Gpr41 both are activated by SCFAs, but with contradictory effects. The negative effect of Gpr41 is counterbalanced by the positive effect of Olfr78, but Gpr41's effect is stronger, so an increase in SCFAs produces an overall decrease in blood pressure.

"We don't have the full story yet," says Pluznick. "There are many players involved in the maintenance of stable levels of blood pressure, and these are just a few of them. We don't know why it would be beneficial for blood pressure to decrease after eating or why gut microbes would play a part in signaling that change. But our work opens the door for exploring the effects of antibiotic treatments, probiotics and other dietary changes on blood pressure levels in mice, and perhaps eventually people."

###

Link to article: http://dx.doi.org/10.1073/pnas.1215927110

Johns Hopkins Medicine: http://www.hopkinsmedicine.org

Thanks to Johns Hopkins Medicine for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 33 time(s).

Source: http://www.labspaces.net/127032/Video__Blood_vessels__sniff__gut_microbes_to_regulate_blood_pressure

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Singer Morrissey says no to Kimmel, 'Duck Dynasty'

LOS ANGELES (AP) ? The TV series "Duck Dynasty" is coming between Morrissey and Jimmy Kimmel.

The singer and animal rights activist says he canceled his appearance Tuesday on ABC's "Jimmy Kimmel Live" because "Duck Dynasty" cast members will be on the talk show.

Morrissey said Monday he can't perform on a show with what he called people who "amount to animal serial killers."

A&E's "Duck Dynasty" reality show follows a Louisiana family with a business selling duck calls and decoys.

A&E did not immediately respond to requests for comment from it and the Robertson family.

A person familiar with the Kimmel show's plans confirmed that Morrissey was to appear. The person lacked authority to discuss the matter publicly and spoke on condition of anonymity.

The person says Morrissey's performance will be rescheduled.

___

Reach AP Television Writer Lynn Elber at http://www.twitter.com/lynnelber .

Source: http://news.yahoo.com/singer-morrissey-says-no-kimmel-duck-dynasty-022936792.html

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Tuesday, February 26, 2013

Horse a hidden ingredient in many European foods

DUBLIN (AP) ? So hungry you could eat a horse? Chances are, if you've regularly consumed processed-meat products in Europe, you already have.

Since Ireland published surprise DNA results on Jan. 15 showing that a third of frozen "beef" burgers in Ireland contained at least a trace of horse, food scientists in more than a dozen countries have found the animal trotting into products where it was never meant to roam.

Daily revelations from an ever-increasing menu of supermarket, catering and restaurant goods have taught the world one lesson: When minced up with other meat or slathered with spices, consumers cannot tell equine from bovine in the food chain. European horse has yet to be detected in any American-sold products.

MEATBALLS

In fairness, IKEA never did call them beef balls. The Swedish furniture giant has discovered that its signature cafeteria dish ? spiced meatballs of mixed beef and pork ? also might contain horse.

Ikea said Monday it was withdrawing stocks of frozen "Kottbullar" meatballs from stores in 24 nations, including Thailand and Hong Kong in Asia and the Dominican Republic in the Caribbean. European countries affected were Austria, Belgium, Britain, Bulgaria, Cyprus, the Czech Republic, Denmark, Finland, France, Germany, Greece, Hungary, Ireland, Italy, the Netherlands, Poland, Portugal, Romania, Slovakia, Spain and Sweden. Somehow, the Swiss were spared.

IKEA was keen to stress that its U.S.-based meatballs were all-American and not subject to recall.

BURGERS

This is the product that started the January stampede to Europe's DNA labs. Irish authorities doing a random quality check were shocked to find horse meat in frozen burgers produced for five Irish and British supermarkets, and eventually traced the source to Poland. The Irish producers' top two customers ? Burger King's British, Irish and Danish restaurants and the British supermarket chain Tesco ? quickly took their business elsewhere.

PIZZA

There's something rotten in Denmark, but it's not the meat itself. The Danish Veterinary and Food Administration says a product enigmatically described as "pizza meat" and sold by the Harby Slagtehus meat wholesaler contains cow, pig and horse. The company insists its customers in pizzerias across Denmark knew the topping contained horse, even if that little fact was nowhere on the ingredients list. Government vets don't believe a word of that.

SPAGHETTI BOLOGNESE

Better make that "bolo-neighs." Many of Europe's leading makers of microwaveable frozen foods ? including Birds Eye of Britain, Nestle of Switzerland, and Findus of France ? found that some suppliers had mixed horse into the ground beef used for Europe's most ubiquitous pasta sauce.

PASTA

Not to beat a dead horse, but Europe's food-testing labs are indicating that any factory-made pasta product containing "beef" sauce or filling might be horse in drag. Among those caught at the DNA finish line are the frozen "beef" lasagnas of Birds Eye; Nestle's Buitoni brand of ravioli in Italy and fusilli in Spain; and Combino-branded tortelloni and penne in Austria. France's Comigel blamed the discovery of up to 100 percent horse in its "beef" lasagnas ? sold under other brand names, including Findus and Tesco ? on a complex supply chain stretching from its Luxembourg factory back via Dutch and Cypriot middlemen to Romania horse butchers.

PASTRIES

Thank goodness there's no such thing (yet) as a beef doughnut. In Spain, Nestle's recall of products includes meat-filled, semicircular pastries called empanadas.

PIES

You might be surprised to find horse meat hiding under a frilly layer of potato. British-style cottage pies, with gravy, beef and carrots under the smashed spuds, have been withdrawn from scores of school cafeterias in England, Wales and Scotland after DNA tests found horse meat inside. France made similar discoveries in its potato-topped pie called hachis Parmentier.

VEGETABLES

Mom might tell you to eat your vegetables, but the Nestle product recall in Spain included meat-stuffed peppers.

KEBABS

Once you've blended a handful of meats, does one more really matter? The Austrians found horse in kebab meat produced by a Vienna firm, Lilla Gastronomie, that was supposed to contain a blend of only beef, pork and turkey.

SAUSAGES

Fry 'er up: Despite sausages' worldwide reputation as a favored destination for mystery meat, only Austria has found equine DNA hiding in sausages, in two brands made by Josef Freitag, aka "Joe Friday."

Source: http://news.yahoo.com/horse-hidden-ingredient-many-european-foods-174118273--finance.html

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Olympus confirms that Sony is now its largest shareholder

Olympus confirms that Sony is now its largest shareholder

Sony got a stake in Olympus' future when it made a $645 million investment into the troubled camera firm last September, getting a board representative and a controlling share of a medical imaging project. As of this weekend, however, the foot is that much further in the door: it's now Olympus' largest shareholder. A share transfer promised alongside the investment, and officially completed on the 22nd, has boosted Sony's stake from 4.7 percent to just under 11.5 percent. The share switch doesn't give Sony enough influence to dictate Olympus' day-to-day affairs, but Sony won't have to do as much to rally support if it wants action. Olympus isn't in the best position to kick such a large investor to the curb, either. We'd expect the company to at least listen more closely to what its major funding source has to say.

Filed under: ,

Comments

Source: Olympus (PDF)

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/yBaWcc-zdaE/

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Frostbite Forces Adventurer to Quit Antarctic Trek

Seasoned adventurer Sir Ranulph Fiennes has had to quit his attempt to be the first person to cross the South Pole on skis during the brutal Antarctic winter.

Fiennes, who has abundant experience in harsh environments, will be evacuated from the coldest continent after developing a case of frostbite, according to a blog post on the website of the expedition, called The Coldest Journey. Fiennes and his team made the decision to have him evacuated while it was still possible before the beginning of the formidable winter, with its near-permanent darkness and temperatures as low as minus 130 degrees Fahrenheit (minus 90 degrees Celsius).

"This decision has not been taken lightly and it is, naturally, a huge disappointment to Fiennes and his colleagues," the post said.

Fiennes will be driven by Ski-Doo, a type of snowmobile, some 40 miles (70 kilometers) from his team's current location to Belgium's Princess Elisabeth Station, located near the coast of East Antarctica, according to the blog post. From there, he will make his way by plane to Cape Town, South Africa.

The evacuation plan is currently being hampered by a blizzard at the team's location.

Once Fiennes is evacuated, the rest of the team has elected to carry on with the journey. They are still slated to begin their crossing on the originally planned date of March 21. The full crossing route will take them from Princess Elisabeth through the interior of the continent to the Amundsen-Scott South Pole Station (named for the two explorers that raced to be the first to the South Pole), then over the Transantarctic Mountains onto the Ross Ice Shelf and to the United States' McMurdo Station, situated on the shore of the Ross Sea. In total, the trek will cover more than 2,000 miles (3,200 km) and take six months.

Fiennes has gone on previous Antarctic and Arctic excursions, climbed to the summit of Mount Everest and run seven marathons in seven days on seven continents, according to his expedition biography.

Reach Andrea Thompson at athompson@techmedianetwork.com and follow her on Twitter @AndreaTOAP and on Pinterest. Follow OurAmazingPlanet on Twitter @OAPlanet. We're also on Facebook and Google+.

Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://news.yahoo.com/frostbite-forces-adventurer-quit-antarctic-trek-223244775.html

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Hiring A Corporate Meeting Room In Melbourne

Meeting rooms in Melbourne guarantee successful meetings when you bring together your partners and people to help achieve your goals. The meeting planners from venues around Melbourne will provide a high level of professionalism and also give attention to fine details no matter if your meeting is small or large. Every meeting venue provides a combination of expertise and innovation and set standards for quality meetings. Venues offer luxury modern meeting rooms and also offer services such as state of the art technology and audio visual support, lunch and dinner experiences, professional meeting planners, custom menus to suit your needs. There are also unique destination activities available to make your meeting a memorable experience.

There are several packages available which include overnight accommodation and breakfast. You can go online and view the many options, additional details and view the rates, services and amenities that are offered with individual attention. Beverages and snacks are on offer throughout the meeting as well as personal concierge to assist yours and your guests needs. Your colleagues, clients and guests will enjoy the best when you choose a premier corporate meeting room Melbourne for your next meeting. When planning a corporate event one should first determine the events objectives and goals, identify possible dates and then prepare a preliminary guest list and agenda. You need to establish a promotional action plan, establish an interaction protocol with sponsors, speakers, staff and the registrants. Set your preliminary budget and review past and current funding resources. Post the meeting info on your website, prepare procedures and policies with regards to the meeting and distribute to your staff. Prepare your calendar of webinars or conference calls and if needed, identify funding from new sources. Prepare a schedule of all printing requirements such as quantity, deadlines, coding systems and other. Assign program responsibilities to the planner and send the meeting requirements with requests for written proposals. At the same time check the venue proposals from venue suppliers and once you have selected a site then you can begin negotiating contracts and agreements. Add requirements and deadlines to your checklist and assign follow up items to team members. If you are exhibiting, provide a tentative floor plan and establish exhibit space rates.

A few months ahead of the meeting, develop a promotional strategy and do some PR work. Monitor your budget, prepare press releases if required and establish preliminary graphics and a meeting theme. Organize your outside supplies such as advertising, modes of transport, audio visual requirements, catering, furniture and equipment, speakers, security and temporary personnel if required. Determine your food and beverage requirements and negotiate menus and prices.

About the Author:
John M Wilson primarily writes articles that offer recommendation about planning and booking for corporate meeting room Melbourne city. If you would like to use any of John Wilsons existing work please visit the grandhotelmelbourne.com.au.

Source: http://www.articlesnatch.com/Article/Hiring-A-Corporate-Meeting-Room-In-Melbourne/4454742

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Monday, February 25, 2013

Video: Matthews: The Oscars show America is ?hungry for a winner?

Sorry, Readability was unable to parse this page for content.

Source: http://video.msnbc.msn.com/hardball/50948432/

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HBT: Rare Honus Wagner card up for auction

I always link to stories about Honus Wagner T-206 cards going up for auction because when I was a kid I was convinced I was going to find one if I looked around in junkyards, garage sales and flea markets long enough. I would have settled for a ?52 Mantle, but the Wagner was really what I was looking for.

That said, even if I had the means, I don?t think I?d get in on the action now. It?s just ? too much:

The card being auctioned at Goldin?s is one of the three highest quality cards in existence. On a scale of 1 to 10, a card graded 8 was bought by Wayne Gretzky in 1991 for $451,000. After a handful of other collectors, it rests now with Ken Kendrick, owner of the the Arizona Diamondbacks, who paid $2.8 million for it in 2007.

Another card, with a 5 grade, was sold to an anonymous buyer in 2008 for $1.62 million.

The card at Goldin?s is also graded 5. It?s been in the hands of a private collector and locked in a bank vault for the past five years.

What a waste. Like this guy doesn?t have a bike with spokes?

I?m more surprised that Kendrick?s is the best quality one out there. While near-mint condition cards are great, you?d think he?d want something more gritty.

Source: http://hardballtalk.nbcsports.com/2013/02/25/a-honus-wagner-card-is-going-up-for-auction/related/

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Sunday, February 24, 2013

Politics ? Abe tells Obama Japan will join child abduction treaty

WASHINGTON ?

Japanese Prime Minister Shinzo Abe told U.S. President Barack Obama on Friday that Tokyo would join a treaty on child abductions, addressing a major concern for lawmakers in Washington.

Japan is the only member of the Group of Eight major industrialized nations that has not signed the 1980 Hague Convention, which requires nations to return snatched children to the countries where they usually reside.

?From the perspective of children, there is an increasing number of international marriages, meaning that there will be some cases where marriages will break down. Therefore we believe it is important to have international rules,? Abe told reporters after talks with Obama.

?We will make efforts in the Diet so that the Convention can be approved. I delivered this message to the president,? Abe told reporters after his meeting with Obama.

However, Abe did not set a timeframe. The previous DPJ government also said it wanted to enter the treaty but did not move ratification through the Diet.

Unlike Western nations, Japan does not recognize joint custody and courts almost always order that children of divorcees live with their mothers.

Hundreds of parents, mostly men, from the United States and elsewhere have been left without any recourse after their estranged partners take their half-Japanese children back to the country.

U.S. lawmakers have repeatedly demanded action from Japan on child abductions, one of the few open disputes between the close allies.

? 2013 AFP

Source: http://www.japantoday.com/category/politics/view/abe-tells-obama-japan-will-join-child-abduction-treaty

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Huawei Ascend P2 hitting Europe in Q2 for 399 euros, we go hands-on

Just ahead of Huawei's press event, Huawei's treated us to an early viewing of its new 8.4-millimeter smartphone, the Ascend P2. With Android 4.1, a quad-core 1.5GHz processor, 13-megapixel camera and a 720p 4.7-inch Gorilla Glass 2 Infinity Edge Display, it joins the likes of the Ascend Mate and D2 in forming the Chinese manufacturer's smartphone family in 2013. And boy, it's a slender, feather-light phone with a glossy backing that come sin both black and white. Design-wise, like those leaks, it looks an awful lot like its predecessor. Its notable feature is the highest-speed LTE connection seen so far in a smartphone, up to 150Mbps with support for LTE Cat4. We also got to play with Huawei's Emotion UI, which can draw on the 1GB of RAM housed inside. There's plenty of storage, with 16GB inside. The right side houses a volume switch and a physical camera button -- these were a bit plasticky, but has a nice matte finish. The other side is where the power button belongs, with both the headphone and micro-USB charging port found there. Huawei's focusing on battery life here as well, with a 2,420mA unit inside and the promise of consuming 20-percent less power, thanks to the handset's display technology.

With the aforementioned Emotion UI, there's the same clipboard animation across homescreen transitions, matching those other Ascend models. Getting into screen performance, it reflected a fair bit of ambient light, perhaps not the best display we've seen from Huawei -- there seems to be a space between the surface of the glass and the display itself. Light, but feels like we were often unable to keep hold of it. The buttons have the right amount of bite, although it would have been nice to see some premium materials used for these minor details. but the design reminds us a fair bit of the Panasonic's Eluga. Perhaps due to the lack of exotic color options, the phone wasn't quite as appealing as when we first got our hands on its predecessors. We'll have a hands-on video up soon. If you're in Europe you can pick this up in Q2 for €399 ($526)

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/xUa4D_11bRc/

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Football - Solo role taxes Torres - Benitez

Sorry, Readability was unable to parse this page for content.

Source: http://www.chelseanews.net/football-solo-role-taxes-torres-benitez/

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Saturday, February 23, 2013

Mali, France and the war on terror in Africa

Is there an imminent threat of terrorism from West Africa?

Horace G. Campbell

2013-02-20, Issue 617

http://pambazuka.org/en/category/features/86326

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INTRODUCTION

Imminent threat is a term used in international law to justify a preemptive military strike. This concept of imminent threat had been articulated prior to the war against the people of Iraq by the George W Bush Administration when the peoples of the world were bombarded with information that Saddam Hussein possessed weapons of mass destruction (WMD). Ten years after the destruction of Iraq with millions killed or displaced, we now know that the case for war had been presented with dubious evidence. Today, there is a new propaganda war, that Jihadists across the Sahel pose an imminent threat to the United States. Recently, U.S. Senator Christopher Coons, chairman of the Senate Foreign Relations Committee stated in Bamako, Mali, that al-Qaeda in Islamic Maghreb (AQIM) posed a ??very real threat? to Africa, the United States and the wider world.?

Who or what is this AQIM? What are its origins? What are their sources of sustenance, finance and logistics?

These questions are not raised when the hype about imminent threat is being bandied about in the media. Both the Washington Post and the New York Times have been prolific in carrying stories about the new threats of terrorism from Africa. Those who do not know about Africa would be carried away by these incessant stories about terrorism in the Sahel, Al Queda in the Horn of Africa and the spread of Islamic terrorists across the length and breadth of Africa.

This idea that AQIM was on the verge of taking over Mali and West Africa had been promoted by France to justify the military intervention under the banner of Operation Serval. France had dispatched approximately 4000 troops to repel Jihadists who had taken over Northern Mali. After these Jihadists seized a number of towns and desecrated important cultural centers, international opinion was sufficiently outraged to mute criticisms of the French intervention. Progressive African opinion was divided over this invasion of Mali as France promoted the idea through a massive propaganda and disinformation campaign that it was ?invited? by the government of Mali. Furthermore, select pictures of Malian citizens celebrating the routing of the Jihadists from towns that had been seized since January 12 gave legitimacy to the idea that Africans welcomed the French military intervention. After this ?successful? intervention, western media outlets are replete with stories that it is the alliance between France and her allies along with the United States that can protect this region of Africa (from Mauritania to Sudan) from being overrun by terrorists. I will argue in this submission that the French intervention is also part of a wider struggle within the Western world and within the foreign policy establishment in Washington.

In a written testimony to the Senate Armed Services Committee, Army Gen. David M. Rodriguez, who has been nominated to be the next leader of the Pentagon?s Africa Command, estimated that the U.S. military needs to increase its intelligence-gathering and spying missions in Africa by nearly 15-fold. Members of the Senate Armed Services Committee who support the expansion of the budget of the Pentagon at a moment of financial crisis for the majority of citizens on the planet pressed General Rodriquez to spell out how the United States will respond to threats and crisis in Africa in the future. This call to beef up the Africa Command is coming from the same section of the foreign and military establishment that opposes Chuck Hagel to become the next Secretary of Defense in the United States.

We are informed by the biographers of Petraeus that General David Rodriquez was mentored by General David Petraues. Even though both Petraeus and General John Allen have been diminished by scandals relating to their conduct, their ideas about terror and counter terror still hold a lot of sway among sections of the foreign and military establishment. This establishment is torn asunder because the United States cannot continue to finance a large military budget without greater austerity imposed on the US society. Black and brown citizens along with other sections of the working poor have borne the brunt of the austerity measures and the transfer of wealth from the poor to the top one per cent inside the United States. These sections of the population have borne the brunt of police harassment and killings. From this domestic policy flowed the foreign policy imperative to kill indiscriminately with drones.

In the context of the confirmation of John Brennan as the Director of the Central Intelligence Agency (CIA) a section of the media was able to get its hands on a Department of Justice white paper, which spells out exactly why it?s perfectly alright for the U.S. to enact extrajudicial assassination of its own citizens by drone strikes. Here was another instance where the idea of imminent threat was being used to justify killings. In the face of the massive anti-war sentiments in the USA, the Pentagon and the CIA resorted to fighting using Special Forces and drones. These drone strikes have killed thousands of persons in Africa and Asia with President Obama giving himself the authority to dispense with human life without trials. One only has to be a suspected terrorist to be targeted. The document is titled ?Lawfulness of a Lethal Operation Directed Against a U.S. Citizen who is a Senior Operational Leader of Al Qa?ida or An Associated Force.? The Memo from the Department of Justice said that its definition of "imminent threat" doesn't require "clear evidence that a specific attack on U.S. persons and interests will take place in the immediate future .?

In the consciousness of the establishment of the United States, Africans had been demonized for decades. Now, with the divisions inside that establishment over its future, and the future projection of military force, Africa is now being conjured again as the scene of instability, violence and terrorism. We will argue in this contribution that it is urgent for the peace and social justice forces internationally to mobilize against this planned remilitarization of Africa. Just as how, ten years after the war against Iraq, we know that the WMD threat was fabricated, it is urgent that the peace forces inside the United States expose the linkages between the military, the Algerian DRS and the Jihadists. This conclusion of this intervention will reassert the claim that it is only the unity of the peoples of Africa across the artificial borders that can start to resolve the outstanding questions of the divisions of peoples such as the Tuareg in differing states. Until the unification of Africa, the Tuaregs will be like the Kurds, manipulated by external forces to suit their own interests.

MALI AND THE TRADITIONS OF PAN AFRICANISM AND UNITY

When the Malian singer Fatoumata Diawara gathered together the cultural artists in Mali on January 17, 2013 at the Voices United for Mali press conference and sang for peace, she was taking the leadership in calling for the people of Africa to join together to bring peace to Mali. She was carrying forward a deep tendency of popular organizing among the people of Mali. The society of Mali sits at the crossroads of numerous tendencies in Africa. One of the proudest tendencies has been the intellectual and cultural history that boasts the archive of the Africa?s contribution to the intellectual culture of humanity with one of the oldest of the institutions centered in the city of Timbuktu. It was this proud tradition that shepherded the reconquest of the independence of the region of West Africa that had been invaded by France after 1830. Because of the cultural and political strength of the independent states beyond the Coast, the imperial penetration of France beyond the coastal areas could only gain ground after the collective military scramble that resulted in the Berlin Conference of 1885.

When France was weakened by World War II, the peoples of West Africa organized to regain their independence and it was in this region where there were the loudest calls for the establishment of a United States of Africa- then called Union of Independent African States. Soon after the independence of Ghana in 1957, the leaders of Ghana, Guinea and Mali proclaimed a unity based on Pan-African cooperation. Kwame Nkrumah of Ghana and Sekou Toure started this union that was later joined by Modibo Ke?ta of Mali. Mark DeLancey in his bibliographical essay on the The Ghana - Guinea - Mali Union: exposed the deep interest in that elementary Union and the deployment of western intellectuals to understand the internal dynamics of that Pan African experiment. [1] After the western intellectuals came the military interventions. First Ghana met the fate of the removal of Nkrumah in 1966 and then in 1968 General Moussa Traor? organized a coup d'?tat against Modibo Ke?ta, and sent him to prison in the northern Malian town of Kidal.

Moussa Traore with the support of external ?donors? dominated the politics of Mali until 1991 when he was removed by an uprising of workers, students and others groups that had fought for the removal of the military from the center of Malian politics. After the overthrow of Traore, Alpha Konare carried forward the Pan African traditions of Mali and went on to become the first Chairperson of the African Union Commission (2003-2008). On the international stage, Konar? worked for peace and integration in the West African region. Among the people of Mali, he understood that the outstanding problems of the place of the Tuareg could not be settled outside of the context of unity and so he worked hard for African unity, serving as president of Economic Community of West African States (ECOWAS) in 1999 and of the West African Monetary Union (UEMOA) in 2000. Leaders such as Keita and Konare were feared by western powers and France maintained a strong military presence in Africa with permanent bases in C?te d'Ivoire, Senegal, Gabon, Chad and Djibouti.

FRENCH MILITARY INTERVENTIONS IN AFRICA

In the book, France Soldiers and Africa, Anthony Clayton laid out in graphic detail the military system of France and its impact on both France and Africa. One of the little known aspects of this militarization of Africa was how the French intellectual culture was negatively affected by the history of military engagement and interventions. Between 1960 and 2012 France had undertaken more than one hundred military interventions in Africa. The lowest point of this engagement and its intellectual variant was when France invaded Central Africa to assist those who were carrying out genocide in Rwanda in 1994.

The embarrassment of shepherding the genocidaires to Zaire and the aftermath of war and destabilization of the entire Eastern African region had led to a temporary retreat by France with the military intellectuals propagating the view that France was reviewing its military policies towards Africa and was going to reform her security policy in Africa, claiming to mark the start of a ?new African politics?.

Nearly fifteen years after the appearance of the book by Clayton, Christopher Griffin wrote a detailed study, French Military Interventions in Africa: French Grand Strategy and Defense Policy since Decolonization. The importance of this study was in the full documentation of how this Grand Strategy was connected by three circles, (a) the national independence of French foreign and defense policy, (b) European defense and (c) a global or geostrategic defense of France?s overseas territories, the DOM-TOM, and other regions and states outside of Europe where French national interests were at stake, primarily in sub-Saharan Africa.

This study of Griffin was written before two major events that changed the world. The first was the capitalist depression and the financial crisis within Europe and North America (after 2008). The second was the revolutionary upheavals within Africa that toppled the regimes of Tunisia and Egypt.

Both of these seismic changes in the international system affected the projection of force by France and this was most clearly manifest in the manipulations by France in relation to the intervention in Libya.[2] Despite the catastrophic failure of that intervention and the instability that has ensued in Africa (with the deepening military engagements in the Sahara), the momentum for French military activities are driven not only by the grand strategy, but by the necessity to draw the United States and the United States Africa Command into a closer alliance, with the US underwriting the intervention by France. The alliance and cooperation between the COIN strategists of the US military and the former colonial generals of France have been well documented and epitomized by the correspondence between General David Petraeus and the late Gen. Marcel Bigeard, 1916-2010. Bigeard had been the quintessential colonial military torturer whose life and exploits followed the colonial and neo-colonial history of France in Africa and IndoChina.

The fall of Petraeus after the elections in the United States in November 2012 had provided one opportunity for the top military brass in the United States to rethink its future, especially at a moment when the crisis of capitalism demanded deep cuts in the military budget. The intervention by France was part of a larger strategy to influence the debate inside the foreign and military policy establishment about whether the war on terror is coming to an end.

Those who are promoting a continuous war on terror have been propagating the idea that West Africa has become a hot bed of terrorism and that the terrorists in the Maghreb threaten the vital interests of the United States. Those who have followed the expenditures of the United States since 2003 in the Trans Sahara Counterterrorism Partnership (TSCTP) and later the US Africa Command will know that of the more than half a billion dollars that was spent, the money went to train many of the forces that are now called terrorist have been trained by the United States. Even from within the corridors of the media in Washington DC writers such as Walter Pincus have documented the huge expenditures of the US military in Mali since 2002. In the same period when the hype of weapons of mass destruction was being propagated by the Bush administration, another fiction was being presented. This was the idea that terrorists were spreading out from Afghanistan and spreading terror from Asia through the Horn of Africa and over to West Africa. This was presented as the banana theory of terrorism and documented in the book, The Dark Sahara: America?s War on Terror in Africa. [3]

Pincus wrote about the monies spent after 2002 in the counterterror offensives in Mali and West Africa. ?With that money, U.S. European Command (EUCOM) sent U.S. Special Forces training units to work with the Mali military.? The fear was that Islamic fighters driven from Afghanistan would settle in northern Mali. Air Force Maj. Gen. Jeffrey B. Kohler, then head of planning at EUCOM, said, ?We?re helping to teach them [the Malian military] how to control this area themselves so they can keep it from being used by terrorists.? [4]

Figures now produced by varying agencies in the USA show that in the counterterror offensives, Mali was the largest recipient of US funds amounting to more than half a billion dollars. The Pentagon had started out with the Pan Sahel Initiative (PSI) but by 2005, the PSI was replaced by the Trans-Sahara Counterterrorism Partnership (TSCTP), a partnership of State, Defense and the U.S. Agency for International Development (USAID) meant to focus on improving individual country and regional capabilities in northwest Africa.

As one writer in the USA summed up this relationship between the USA and the corrupt military establishment in Mali, ?In the past decade, the U.S. alone has poured close to $1 billion into Mali, including development aid as well as military training to battle an al-Qaida offshoot in the north. In doing so, the U.S. unwittingly also helped prepare the soldiers for the coup: Sanogo himself benefited from six training missions in the U.S., the State Department confirmed, starting in 1998 when he was sent to an infantry training course at Fort Benning, Ga. He returned in 2001, 2002, 2004, 2008 and 2010 to attend some of the most prestigious military institutions in America, including the Defense Language Institute at the Lackland Air Force Base, Texas. He took a basic officer course at Quantico, Virginia, and learned to use a light-armored vehicle at Camp Pendleton, Calif.?

The aid packages to Mali represented a systematic buildup of the US military involvement in the Sahel region, with a focus on Mali because of the strong history of popular struggles for democratic change in Mali. As far back as November 2009, in his testimony before the Senate Subcommittee on Africa hearing on 'Counter-terrorism in the Sahel' on 17 November 2009, Secretary of State for Africa Johnnie Carson identified Mali ? along with Algeria, Mali, and Mauritania ? as one of the 'key countries' in the region for the US counter-terrorism strategy. ?We believe that our work with Mali to support more professional units capable of improving the security environment in the country will have future benefits if they are sustained?, he stated.

The current insecurity in Mali is a direct result of the US military presence and the instability represents one more piece of evidence why Africans must be more forthright in opposing the expansion of the US Africa Command. It was when the full extent of the US engagement with the forces in combat became known that the lame duck leader of AFRICOM, General Carter Ham, admitted, ?We made mistakes.? [5]

USA ON THE WRONG SIDE OF HISTORY

The US foreign policy establishment was always on the defensive in relation to the formulation of policies towards Africa, because their domestic policy towards Africans has been dominated by racism. During the era of colonialism and apartheid the US foreign policy was informed by the support for the white racist regimes in Africa and for dictators. From the assassination of Patrice Lumumba in 1960 to the execution of Muammar Gaddafi in October 2011, the US hard interests have been dominated by oil, needs of finance capital (IMF), wars, and global US diplomatic and military hegemony. The US Africa Command is the latest iteration of the combination of these hard interests with the counter-terrorism discourse losing its luster. During the period of the support for apartheid, when the peoples of Angola were about to defeat the South African racist army at Cuito Cuanavale, the United States mounted Operation Flintlock to give support to the white racist regime.

In the era of ?counterterror, Operation Flintlock was again launched to spread instability and corruption in the Sahel. Operation Flintlock exercises were held in Mali in 2007 and 2008. In 2009, Mali got equipment worth $5 million, including 37 ?new Land Cruiser pickup trucks, along with powerful communications equipment? for the desert, according to a U.S. statement. Mali also got $1 million in U.S. mine-detector equipment.

WHO OR WHAT IS AQIM?

For this author, AQIM has the same status as the weapons of mass destruction that was supposed to be in Iraq. From the time of the launch of the Pan Sahel Initiative, the United States had partnered with repressive regimes in the region of North and West Africa. Moammar Gaddaffi had gone out of his way to ingratiate himself with the United States associating with the war on terror, until the United States and France turned to the very same jihadists to remove Gaddafi. The names and personalities have been changing over the past ten years but there is a certain consistency with which there has been shifting allegiances in North Africa. One allegiance that has been constant has been the relationship between the US military and intelligence services with the Algeria Secret Police DRS (D?partement du Renseignement et de la S?curit?) Department of Intelligence and Security (DRS).

From the period of the well documented Dirty War in Algeria that started in 1992, there has been documented evidence of the fabrication of terrorism by this DRS. Habib Soua?dia, a former military officer from Algeria has written for posterity the role of the DRS in the ?netherworld of torture, murder and terrorism. [6] The book by Souaidia about the world of the Generals of the DRS had been written before September 11, 2001. After the Global War on Terror was declared by George W. Bush, the neo-conservatives embraced the DRS as an ally and partner to fight terrorism. Haliburton entered into the lucrative business of building defense institutions as well as profiting from the oil and gas business in Algeria. The collusion between the firms such as Haliburton and the DRS has been documented. Although the complex linkages between terrorism, corruption and a section of the politico-military power concealed the exact base for support for AQIM, from inside the national Security apparatus in Washington there were writers who exposed the overlap between governments, smugglers, drug dealers and those who were dubbed as terrorists. [7]

Western news agencies such as the BBC have been running stories on ?Mali's main Islamist militants.? These stories have listed five main Islamists groups in Mali and the Sahel. The sixth group is from time to time listed with the groups that are called Jihadists.

These are:
1. Ansar Dine ? identified as one movement with a number of Tuareg fighters who returned from Libya after fighting alongside Muammar Gaddafi's troops.

2. Islamic Movement for Azawad - an offshoot of Ansar Dine which says it rejects "terrorism" and wants dialogue

3. Al-Qaeda in the Islamic Maghreb (AQIM) - al-Qaeda's North African wing, with roots in Algeria

4. Movement for Unity and Jihad in West Africa (Mujao) - an AQIM splinter group whose aim is to spread jihad to the whole of West Africa

5. Signed-in-Blood Battalion - an AQIM offshoot committed to a global jihad and responsible for Algerian gas facility siege.

6. The National Movement Liberation of Azawad (MNLA) is a secular Tuareg group which seeks independence for a homeland they call Azawad [8]

The shifting alliances of these so-called jihadists that were supposed to have threatened Bamako , West Africa and the world are then reproduced by other western journalists without the kind of critical examination of the roots of these organizations. Given the history of the US counter-terror operations and the shifting alliances it would be important for the Senate Armed Services Committee to investigate the claim of Jeremy Keenan that ?at the heart of AQIM is the DRS.? [9]

African progressives have to seriously investigate the relationship between the DRS and these so-called jihadists because Algeria has been one of the strongest supporters of the African Union and the African Liberation Project. Up to today the diplomats of Algeria are held in the highest regard within the corridors of the African Union and the Algerian leadership has gained praise for its unstinting support for the independence of Western Sahara. From the period of the internal war against Islamists in 1992, there had been numerous stories about the DRS and its role in corruption and torture. Algeria and the DRS consider the Sahel to be the backyard of Algeria and hence it has been difficult to separate drug traffickers, smugglers of cigarettes, Jihadists, and corrupt secret services in this region.

From the evidence provided by the Government Accountable Office of the United States, the large sums of money expended by the United States in Mali since 2005 went to support some of the regional barons who were involved in underground channels that overlapped with the jihadists. A leader of the so called jihadists called Iyad Ag Ghaly has enjoyed the support of leaders inside and outside of Mali functioning at one moment as the envoy of Mali in Saudi Arabia. [10] An unflattering profile of Iyad Ag Ghaly, ?Mali's whisky-drinking rebel turned Islamist chief,? [11] gives some indication of the interpenetration between terror, counter terror, the world of drug dealers, kidnappers and organized mafia groups.

African progressives and intellectuals will have to work hard to expose the linkages between Saudi Arabia, Qatar, the United States conservatives and the jihadists across West Africa. One direct result of the Libya intervention was the reality that France, the United States and Britain financed the Islamist forces who they are now supposed to be fighting. For the past sixty years, France intervened militarily ostensibly to protect French nationals but in the main, these interventions have been to support corrupt and unpopular leaders.

When General Gen. David M. Rodriguez, who is poised to become the next leader of the Pentagon?s Africa Command, estimated that the U.S. military needs to increase its intelligence-gathering and spying missions in Africa, it is important to point out that the Obama administration is empowering a general who was mentored by General David Petraeus.

WHAT LESSONS MUST BE LEARNT FROM THE PRESENT INSTABILITY IN MALI?

There are many lessons to be learnt from the role of France, the United States and Britain in North and West Africa. From Africa, one of the most important lessons is to draw from the discourse on imminent threat to be able to isolate those corrupt officials who participate with external forces in counter-terror activities. And then, ten years later turn around and start to fight wars against the very same forces that they have trained and nurtured. There was no time when the forces of the jihadists numbered more than 6000. It is clear that France jumped the gun to intervene pre-empting the deployment of the forces of ECOWAS. International pundits blamed Africans for their slowness in responding to the takeover of Northern Mali. Experience from Sierra Leone and from Liberia pointed to the capabilities of forces from ECOWAS, especially Nigeria, to eradicate forces of military destabilization.

There are divisions between progressive Africans as to the danger that was presented by AQIM. These divisions should not divert attention from the fact that the Tuaregs have real grievances all across the region of the Sahel. The challenges of resolving the outstanding questions of self-determination and autonomy for the Tuareg in this region cannot be carried out in the context of the present borders. The French intellectuals and military understand this and hence, France has presented itself as a supporter of the Tuareg while jumping in to fight other sections of the Tuareg.

The African people know full well that the so-called jihadists have been those who were trained and supported by the USA, the DRS with finance from Qatar and Saudi Arabia. In reality, in order to root out terror in Africa, it will be necessary to excise the sources of funding that is flowing to the Wahabists. The bulk of the weapons and finance for these jihadists come from allies of the USA where the Wahabist forces are financially and militarily well endowed.

The entire Sahara region abuts the revolutionary zone of Egypt. Every society in North Africa is threatened by revolutionary uprisings. The inequalities and exploitation of the poor all across the region have provided fertile ground for revolutionary openings. Qatar, Saudi Arabia and the USA understand the potential for change after Tahrir Square, hence the tremendous investments to remilitarize this entire region.

BEYOND THE IMMINENT THREAT

Ten years after the war in Iraq and two years after the NATO intervention in Libya, the western media is again preparing citizens of the West for an escalation of military destabilization of Africa. Since last November, there has not been a week when the western media did not carry a story about how AQIM threatens the west. From these reports, carried especially in the Washington Post and the New York Times, one may be forgiven if one forgets that there is another dynamic at work in Africa, that of a new force of economic dynamism across the continent.

The recent report about the location of US surveillance drones in Niger was another instance of hyping the so-called terror threat from Africa. The reporting in the New York Times on ?U.S. Weighs Base for Spy Drones in North Africa? was part of a wider ongoing debate within the Administration about the future of the US military budget. The New York Times is part of this debate and is on the side of those who want to see the maintenance of the high military budget. In the past 50 years there has not been a major war or deployment of US military force that the New York Times opposed. This organization supported the war in Afghanistan, Iraq, Libya and now the expansion of western military intervention in North Africa. The reporting in my opinion is part of the effort to promote the idea that Africa is a hotbed of terrorist activity and that the rag tag groups that are called jihadists are a threat to the United States.

This is patently false.

What needs to be done is for there to be a clear assessment of how much the US military supported some of these same groups that they are now fighting. When Jeh Charles Johnson, the Defense Department?s general counsel, gave a speech in Oxford in November to say that the war on terror is not endless and that there will be a time when this mopping up of terrorists will be a police operation, the New York Times did not give this story the same exposure as European papers. The item was front and center for British newspapers such as the Guardian. In his speech Jeh Johnson held that, ?When that point is reached, the primary responsibility for mopping up scattered remnants of the group and unaffiliated terrorists will fall to United States law enforcement and intelligence agencies, and pressing questions will arise about what to do with any military detainees who are still being held without trial as wartime prisoners.?

?I do believe that on the present course, there will come a tipping point ? a tipping point at which so many of the leaders and operatives of Al Qaeda and its affiliates have been killed or captured and the group is no longer able to attempt or launch a strategic attack against the United States, such that Al Qaeda as we know it, the organization that our Congress authorized the military to pursue in 2001, has been effectively destroyed.?

Jeh Johnson did not survive in the pentagon much longer after this speech. The present struggles over the next Secretary of Defense in the United States is intricately linked to the struggle of whether the CIA and the military can continue to create terrorists and then turn around and fight them. One indication of this tension in the administration was exposed when Senator John McCain questioned Leon Panetta (Outgoing Secretary of Defences) on the US military support for those fighting the Assad regime. In testimony before the Senate Armed Services Committee in early February, Defense Secretary Leon E. Panetta acknowledged that he and the chairman of the Joint Chiefs of Staff, Gen. Martin E. Dempsey, had supported a plan last year to arm carefully vetted Syrian rebels. But it was ultimately vetoed by the White House, Mr. Panetta said, although it was developed by David H. Petraeus, the C.I.A. director at the time, and backed by Hillary Rodham Clinton, then the secretary of state.? [12]

The CIA had been using Libya as a base for the recruitment of jihadists to fight in Syria. Some of the very same groups that had been trained by the CIA are now fighting in Mali.

This kind of duplicity is not new in Africa. For the past twenty years, the Pentagon and the CIA have been fighting on both sides in Somalia. When insiders from the western establishment warn that there is a new phase of a war on terror in Africa, serious policy makers in Africa and beyond should take serious note. It has now devolved to the integrated East African Community to bring in Somalia and carry out a process of demilitarization. Such a process of demilitarization weakens the hands of those in the USA who see Africa as a hotbed of terrorism. The present struggles in Mali require new commitment for social and economic transformation in Africa, especially incorruptible leaders who can resist drug dealers, jihadists and smugglers. It is in Nigeria where the forces of destabilization are most active because these forces understand that a democratic and committed Nigeria will be a major force for unity and emancipation in Africa.

* Horace G Campbell is a professor of African American Studies and Political Science at Syracuse University in Syracuse, NY. He has a book coming out in March titled, ?Global NATO and the Catastrophic Failure in Libya?.

END NOTES

[i] Mark Delancey, ?The Ghana - Guinea - Mali Union: A Bibliographic Essay? African Studies Bulletin > Vol. 9, No. 2, Sep., 1966 ,

[ii] Horace Campbell, Global NATO and the Catastrophic Failure in Libya, Monthly Review Press, New York 2013

[iii] Jeremy Keenan, The Dark Sahara: America?s War on Terror in Africa, Pluto Press London 2009

[iv] Walter Pincus, ?Mali insurgency followed 10 years of U.S. counterterrorism programs,? Washington Post, January 16, 2013, http://tinyurl.com/b5q8epq

[v] http://www.bbc.co.uk/news/world-africa-21195371

[vi] NICHOLAS LE QUESNE, Algeria?s Shameful war, Time Magazine, April 16, 2001 http://www.time.com/time/magazine/article/0,9171,105720,00.html

[vii] John Schindler, ?The Ugly truth about Algeria.? The National Interest 10 July 2012. http://nationalinterest.org/commentary/the-ugly-truth-about-algeria-7146

[viii] BBC , Mali Crisis: Key Players, http://www.bbc.co.uk/news/world-africa-17582909

[ix] Jeremy Keenan, 'Secret hand' in French Sahel raid,? Al Jazeera, August 29, 2010, http://www.aljazeera.com/focus/2010/08/201085183329292214.html

See also John Schindler, ?Algeria?s hidden hand.? The National Interest 22 January 2013. http://tinyurl.com/bzfw5se and Jeremy Keenan, ?A New Phase in the War on Terror?: ? International State Crime Initiative, February 14, 2013, http://tinyurl.com/a5p3kl7

[x] Peter Beumont, ?The man who could determine whether the west is drawn into Mali's war,? Guardian UK, October 27, 2012, http://tinyurl.com/bjz4xat
[xi] Leela Jacinto, ?Mali's whisky-drinking rebel turned Islamist chief,? http://tinyurl.com/8g547nm

[xii] Michael Gordon and Mark Landler, ? Senate Hearing Draws Out a Rift in U.S. Policy on Syria,? New York Times, February 7, 2013, http://tinyurl.com/ase9347

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Yo! Theo's Here!

Hello all! I'm Theodora. Or you could call me Theo as my friends do.

I was introduced to the idea of role playing some years back and since then, I've been doing it fairly often. I love the freedom that a role play grants people so it's even more exciting for me to know that such a large community like this exists for the purpose of role-playing!

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Flipping the 'off' switch on cell growth: Protein uses multiple means to help cells cope when oxygen runs low

Feb. 22, 2013 ? A protein known for turning on genes to help cells survive low-oxygen conditions also slows down the copying of new DNA strands, thus shutting down the growth of new cells, Johns Hopkins researchers report. Their discovery has wide-ranging implications, they say, given the importance of this copying -- known as DNA replication -- and new cell growth to many of the body's functions and in such diseases as cancer.

"We've long known that this protein, HIF-1?, can switch hundreds of genes on or off in response to low oxygen conditions," says Gregg Semenza, M.D., Ph.D., a molecular biologist who led the research team and has long studied the role of low-oxygen conditions in cancer, lung disease and heart disorders. "We've now learned that HIF-1? is even more versatile than we thought, as it can work directly to stop new cells from forming." A report on the discovery appears in the Feb. 12 issue of Science Signaling.

With his team, Semenza, who is the C. Michael Armstrong Professor of Medicine at the Johns Hopkins University School of Medicine's Institute for Cell Engineering and Institute for Genomic Medicine, discovered HIF-1? in the 1990s and has studied it ever since, pinpointing a multitude of genes in different types of cells that have their activity ramped up or down by the activated protein. These changes in so-called "gene expression" help cells survive when oxygen-rich blood flow to an area slows or stops temporarily; they also allow tumors to build new blood vessels to feed themselves.

To learn how HIF-1?'s own activity is controlled, the team looked for proteins from human cells that would attach to HIF-1?. They found two, MCM3 and MCM7, that limited HIF-1?'s activity, and were also part of the DNA replication machinery. Those results were reported in 2011.

In the new research, Semenza and his colleagues further probed HIF-1?'s relationship to DNA replication by comparing cells in low-oxygen conditions to cells kept under normal conditions. They measured the amount of DNA replication complexes in the cells, as well as how active the complexes were. The cells kept in low-oxygen conditions, which had stopped dividing, had just as much of the DNA replication machinery as the normal dividing cells, the researchers found; the difference was that the machinery wasn't working. It turned out that in the nondividing cells, HIF-1? was binding to a protein that loads the DNA replication complex onto DNA strands, and preventing the complex from being activated.

"Our experiments answered the long-standing question of how, exactly, cells stop dividing in response to low oxygen," says Maimon Hubbi, Ph.D., a member of Semenza's team who is now working toward an M.D. degree. "It also shows us that the relationship between HIF-1? and the DNA replication complex is reciprocal -- that is, each can shut the other down."

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The above story is reprinted from materials provided by Johns Hopkins Medicine, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. M. E. Hubbi, Kshitiz, D. M. Gilkes, S. Rey, C. C. Wong, W. Luo, D.-H. Kim, C. V. Dang, A. Levchenko, G. L. Semenza. A Nontranscriptional Role for HIF-1? as a Direct Inhibitor of DNA Replication. Science Signaling, 2013; 6 (262): ra10 DOI: 10.1126/scisignal.2003417

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/XQflXj1NWK4/130223111517.htm

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